Publications

August 21, 2020

High levels of ubidecarenone (oxidized CoQ 10) delivered using a drug-lipid conjugate nanodispersion (BPM31510) differentially affect redox status and growth in malignant glioma versus non-tumor cells

Scientific Reports; 2020 August 17;10(1):13899 Jiaxin Sun, Chirag B Patel, Taichang Jang, Milton Merchant, Chen Chen, Shiva Kazerounian, Anne R Diers, Michael A Kiebish, Vivek K Vishnudas, Stephane Gesta, Rangaprasad Sarangarajan, Niven R Narain, Seema Nagpal, Lawrence Recht Metabolic reprogramming in cancer cells, vs. non-cancer cells, elevates levels of...

July 22, 2020

Divergence in the metabolome between natural aging and Alzheimer’s disease

Scientific Reports; 2020 July 22;10(1):12171 Holly C Hunsberger, Bennett P Greenwood, Vladimir Tolstikov , Niven R Narain , Michael A Kiebish , Christine Ann Denny Alzheimer’s disease (AD) is a progressive and debilitating neurodegenerative disorder and one of the leading causes of death in...

July 16, 2020

Bayesian model infers drug repurposing candidates for treatment of COVID-19

Submitted for peer review. This abstract has been posted online to share with the scientific community given the severity of the COVID pandemic Michael A. Kiebish, Punit Shah, Rangaprasad Sarangarajan, Vivek K. Vishnudas, Stephane Gesta, Poornima...

July 6, 2020

Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity

GeroScience; 2020 July 6; doi: 10.1007/s11357-020-00221-0 Justin Darcy, Yimin Fang, Samuel McFadden, Matthew D. Lynes, Luiz O. Leiria, Jonathan M. Dreyfuss, Valerie Bussburg, Vladimir Tolstikov, Bennett Greenwood, Niven R. Narain, Michael A. Kiebish, Andrzej Bartke, Yu-Hua...

May 29, 2020

Current Status of Metabolomic Biomarker Discovery: Impact of Study Design and Demographic Characteristics

Metabolites; 2020 May 29;10(6):E224 Vladimir Tolstikov, A James Moser, Rangaprasad Sarangarajan, Niven R Narain, Michael A Kiebish Widespread application of omic technologies is evolving our understanding of population health and holds promise in providing precise guidance for selection of therapeutic...

May 29, 2020

Older adults with sarcopenia have distinct skeletal muscle phosphodiester, phosphocreatine, and phospholipid profiles

Aging Cell; 2020 May 28;e13135 James Matthew Hinkley, Heather H. Cornnell, Robert A. Standley, Emily Y. Chen, Niven R. Narain, Bennett P. Greenwood, Valerie Bussberg, Vladimir V. Tolstikov, Michael A. Kiebish, Fanchao Yi, Rick B. Vega,...

January 1, 2020

Skeletal muscle energetics and mitochondrial function are impaired following 10 days of bed rest in older adults

The Journals of Gerontology: Series A 2020 Jan;pii: glaa001. doi: 10.1093/gerona/glaa001 Standley RA, Distefano G, Trevino MB, Chen E, Narain NR, Greenwood B, Kondakci G, Tolstikov VV, Kiebish MA, Yu G, Qi F, Kelly DP, Vega RB, Coen PM, Goodpaster BH Older adults exposed to periods of inactivity during hospitalization, illness...

November 4, 2019

A Data-Driven Approach to Predicting Septic Shock in the Intensive Care Unit

Biomedical Informatics Insights. 2019 Nov 4;11, 1178222619885147 Christopher R Yee, Niven R Narain, Viatcheslav R Akmaev, Vijetha Vemulapalli Early diagnosis of sepsis and septic shock has been unambiguously linked to lower mortality and better patient outcomes....

October 1, 2019

12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat

Cell Metabolism. 2019 Oct;30(4):768-783.e7 Luiz Osório Leiria, Chih-Hao Wang, Matthew D. Lynes, Kunyan Yang, Farnaz Shamsi, Mari Sato, Satoru Sugimoto, Emily Y. Chen, Valerie Bussberg, Niven R. Narain, Brian E. Sansbury, Justin Darcy, Tian Lian Huang,...

September 5, 2019

BAIcis: A novel Bayesian network structural learning algorithm and its comprehensive performance evaluation against open-source software

Journal of Computational Biology. 2019 Sep 5;doi: 10.1089/cmb.2019.0210 Lixia Zhang, Leonardo O Rodrigues, Niven R Narain, Viatcheslav R Akmaev Structural learning of Bayesian networks (BNs) from observational data has gained increasing applied use and attention from various scientific and...

September 1, 2019

A metabolic perspective on CSF-mediated neurodegeneration in multiple sclerosis

Brain. 2019 Sept; 1;142(9):2756-2774 Wentling M, Lopez-Gomez C, Park HJ, Amatruda M, Ntranos A, Aramini J, Petracca M, Rusielewicz T, Chen E, Tolstikov V, Kiebish M, Fossati V, Inglese M, Quinzii CM, Katz Sand I, Casaccia...

September 1, 2019

Diablo ubiquitination analysis by sandwich immunoassay

Journal of Pharmaceutical and Biomedical Analysis. 2019 Sept;173:40-46 Guven A, Wu WS, Patil S, Gokul K, Tekumalla P, Sharma S, Diers A, Gesta S, Vishnudas V, Sarangarajan R, Kellogg MD, Narain NR, Kiebish MA. Ubiquitin plays...

June 1, 2019

Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.

iScience. 2019 Jun;16:230-241 Haraszti RA, Miller R, Dubuke ML, Rockwell HE, Coles AH, Sapp E, Didiot MC, Echeverria D, Stoppato M, Sere YY, Leszyk J, Alterman JF, Godinho BMDC, Hassler MR, McDaniel J, Narain NR, Wollacott...

May 1, 2019

Body Mass Index in Multiple Sclerosis modulates ceramide-induced DNA methylation and disease course.

EBioMedicine. 2019 May;43:392-410 Castro K, Ntranos A, Amatruda M, Petracca M, Kosa P, Chen EY, Morstein J, Trauner D, Watson CT, Kiebish MA, Bielekova B, Inglese M, Katz Sand I, Casaccia P. Multiple Sclerosis (MS) results...

May 1, 2019

Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma.

Communications Biology. 2019 May;2: 200 Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, Kondakci G, Narain NR, Kiebish MA, Bronson RT, Arismendi-Morillo G, Chinopoulos C, Seyfried TN. Glioblastoma (GBM) is an aggressive...

February 1, 2019

A peroxidized omega-3-enriched polyunsaturated diet leads to adipose and metabolic dysfunction

Journal of Nutritional Biochemistry. 2019 Feb;64:50-60  James L. Miller, Magdalena Blaszkiewicz, Cordell Beaton, Cory P. Johnson, Stephen Waible II, Amanda L. Dubois, Amanda Klemmer, Michael A. Kiebish, Kristy L. Townsend Consumption of diets that differ in...

January 1, 2019

Genomic Alterations of Tenascin C in Highly Aggressive Prostate Cancer: A Meta-analysis

Genes & Cancer. 2019;10(5-6):150-159 Prachi Mishra, Michael A. Kiebish, Jennifer Cullen, Alagarsamy Srinivasan, Aaliyah Paterson, Rangaprasad Sarangarajan, Niven R. Narain, Albert Dobi Tenascin C (TNC), an extra-cellular matrix (ECM) family gene, is expressed in several cancer...

January 1, 2019

Omics Driven Medicine for Democratizing Healthcare Delivery and Health Economics

Handbook of Biomarkers and Precision Medicine. 2019 Chapter 9.7, CRC Press Michael A. Kiebish, Viatcheslav R. Akmaev, Vivek Vishnudas, Stephane Gesta, Rangaprasad Sarangarajan, Niven R. Narain

January 1, 2019

Identification of Biomarkers for the Diagnostics, Prediction, and Progression of Alzheimer’s Disease

Handbook of Biomarkers and Precision Medicine. 2019 Chapter 8.7, CRC Press Bennett P. Greenwood, Vladimir Tolstikov, Paula P. Narain, Jeremy Chaufty, Viatcheslav R. Akmaev, Vivek Vishnudas, Stephane Gesta, Eric J. Nestler, Rangaprasad Sarangarajan, Niven R. Narain,...

January 1, 2019

Multi-omic serum biomarkers for prognosis of disease progression in prostate cancer

Journal of Translational Medicine. 2019 Jan;18(1):10 Kiebish MA, Cullen, Mishra P, Ali A, Milliman E, Rodrigues LO, Chen EY, Tolstikov V, Zhang L, Panagopoulos K, Shah P, Chen EY, Petrovics G, Rosner IL, Sesterhenn IA, McLeod DG, Granger E, Sarangarajan R, Akmaev V, Srinivasan A, Srivastava S, Narain NR, Dobi A Predicting the clinical course of prostate cancer...

January 1, 2019

Enabling biomarker discovery in Parkinson’s Disease Using Multiomics: Challenges, promise and the future

Personalized Medicine. 2019 Jan;16(1):5-7 Michael A. Kiebish, Niven R. Narain Overview of the current state of biomarker discovery in Parkinson’s disease as well as the opportunity of using multi-omic discovery approach for engagement of novel biomarkers...