Publications

July 17, 2018

Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism

Lynes et al., 2018, Cell Reports 24, 781–790 Authors: Matthew D. Lynes, Farnaz Shamsi, Elahu Gosney Sustarsic, Zachary Gerhart-Hines, Michael A. Kiebish, Yu-Hua Tseng In this resource, Lynes et al. use a sensitive MS/MSALL technique to...

July 3, 2018

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis

Cell Metabolism 28, 1–16 Authors: Elahu G. Sustarsic, Tao Ma, Matthew D. Lynes, Yu-Hua Tseng, Nils J. Færgeman, Zachary Gerhart-Hines Sustarsic et al. reveal that synthesis of the mitochondrial phospholipid cardiolipin is a hallmark of brown and...

June 21, 2018

Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a b3-Adrenergic Receptor Agonist

Lynes et al., 2018, Cell Reports 24, 781–790 Authors: Alison S. Baskin, Joyce D. Linderman, Robert J. Brychta, Suzanne McGehee, Esti Anflick-Chames, Cheryl Cero, James W. Johnson, Alana E. O’Mara, Laura A. Fletcher, Brooks P. Leitner,...

May 1, 2018

Cell Metabolism:12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake

Stanford et al., 2018, Cell Metabolism 27, 1111–1120 May 1, 2018 ª 2018 Elsevier Inc. Authors: Kristin I. Stanford, Matthew D. Lynes, Hirokazu Takahashi, Yu-Hua Tseng, Paul M. Coen, Laurie J. Goodyear Using an MS/MSALL lipidomics...

April 25, 2018

Prophylactic ketamine alters nucleotide and neurotransmitter metabolism in brain and plasma following stress

Neuropsychopharmacology (2018) 0:1-9 Authors: Josephine C. McGowan, Collin Hill, Alessia Mastrodonato, Christina T. LaGamma, Alexander Kitayev, Rebecca A. Brachman, Niven R. Narain, Michael A. Kiebish and Christine A. Denny Recently, we have shown that ketamine given prior...

April 12, 2018

Perturbation of the yeast mitochondrial lipidome and associated membrane proteins following heterologous expression of Artemia-ANT

Scientific REPOrTS | (2018) 8:5915 Authors: Emily Chen, Michael A. Kiebish, Justice McDaniel, Katarzyna Niedzwiecka, Roza Kucharczyk, Dora Ravasz, Fei Gao, Niven R. Narain, Rangaprasad Sarangarajan, Thomas N. Seyfried, Vera Adam-Vizi, & Christos ChinopoulosRoberto E. Floresa,...

March 19, 2018

Mycoplasma infection and hypoxia initiate succinate accumulation and release in the VM-M3 cancer cells

Flores, R.E., BBA – Bioenergetics (2018) Authors: Roberto E. Floresa, Ashley K. Browna, Luke Tausa, Julianna Khourya, Frank Glovera, Kenjiro Kamib, Rangaprasad Sarangarajanc, Tony E. Walshec, Niven R. Narainc, Michael A. Kiebishc, Laura M. Sheltonb, Christos...

January 12, 2018

A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells

BMC Genomics. (2017) 18: 987 Authors: Jialiang Yang, Jacob Hagen, Kalyani V. Guntur, Kimaada Allette, Sarah Schuyler, Jyoti Ranjan, Francesca Petralia, Stephane Gesta, Robert Sebra, Milind Mahajan, Bin Zhang, Jun Zhu, Sander Houten, Andrew Kasarskis, Vivek...

January 12, 2018

Human CCDC47 sandwich immunoassay development with electrochemiluminescence technology

Journal of Immunological Methods, 2018, 452:12 Authors: Wenfang S. Wu, Liang Zhu, Saurabh Patil, Karthiga Gokula, Sean Reilly, Joyce Chan, Poornima Tekumalla, Vivek Vishnudas, Michael A.Kiebish, Rangaprasad Sarangarajana, Viatcheslav R. Akmaev, Mark D.Kellogg, Niven R.Narain Coiled-Coil...

October 11, 2017

Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species

WILEY AOCS (2017)  Authors: Fei Gao · Justice McDaniel · Emily Y. Chen · Hannah E. Rockwell · Cindy Nguyen · Matthew D. Lynes · Yu-Hua Tseng · Rangaprasad Sarangarajan · Niven R. Narain · Michael...

July 21, 2017

Integrated Metabolomics Assessment of Human Dried Blood Spots and Urine Strips

Metabolites, 2017 7(3), 35. BERG developed dried blood spot and dried urine strip workflow using metabolomics platform for potential precision medicine and population health applications. Authors: Jeremy Drolet, Vladimir Tolstikov, Brian Williams, Bennett Greenwood, Collin Hill,...

April 13, 2017

Blood sampled through dried blood spots (DBS) exhibits diminished ex vivo metabolism compared to whole blood through use of a kinetic isotope-labeling metabolomics approach

Biochemistry and Analytical Biochemistry, 2017, 6:2. BERG researchers investigate alternative methods for assessing metabolism in biofluids using an isotope labeling metabolomics approach through dried blood spot analysis. Authors: Collin Hill, Jeremy Drolet, Mark Kellogg, Vladimir Tolstikov,...

April 13, 2017

Clinical Validation of a Serum Protein Panel (FLNA, FLNB and KRT19) for Diagnosis of Prostate Cancer

Journal of Molecular Biomarkers and Diagnosis, 2017, 8:2, 323. Ravipaty, et al. BERG, LLC, collaborated with Mount Sinai Hospital Toronto to develop and test a novel serum protein panel of three prostate cancer biomarkers for use...

April 13, 2017

CoQ10 selective miscibility and penetration into lipid monolayers with lower lateral packing density

Biochimica et Biophysica Acta, 2017. Garg, et al. BERG, LLC, investigated the biophysical properties of BPM31510, a compound currently in clinical trials for cancer, and demonstrated that the selective incorporation of BPM31510 into cancer cells is...

April 10, 2017

Dynamic and temporal assessment of human dried blood spot MS/MS shotgun lipidomics analysis

Nutrition and Metabolism, 2017, 14: 28. Gao, et al. BERG, LLC, develops a novel mass spectrometry-based method to analyze lipid species from dried blood spot cards which can be used for precision medicine applications and in...

April 10, 2017

Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses

Mediators of Inflammation, 2017, Dowal, et al. BERG, LLC, demonstrates that white adipose tissue and macrophages are connected to the induction of low-grade inflammation, whereas brown adipose tissue and macrophages are not; introducing the possibility of...

April 10, 2017

Clinical Metabolomics: A Pivotal Tool for Companion Diagnostic Development and Precision Medicine

Expert Reviews of Molecular Diagnostics, Vol 17, 2017, Tolstikov, et al. – Metabolomics is an essential component of a precision medicine-based strategy for diagnostic and disease therapy. Authors: Vladimir Tolstikov, Viatcheslav R. Akmaev, Rangaprasad Sarangarajan, Niven...

April 10, 2017

Predicting Prostate Cancer Progression as a Function of ERG Status, Race & Obesity in a Longitudinal Patient Cohort

European Urology Focus 2017, Cullen et al. –BERG, LLC, collaborates with the Walter Reed National Military Medical Center and Center for Prostate Disease Research (CPDR) to investigate a large, racially diverse military population demonstrating that ERG...

February 17, 2017

Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling

Cell Reports, 2017, May et al.- BERG collaborates with Joslin Diabetes Center, Boston, to characterize the lipidome of white and brown adipose tissue in response to exercise Francis J. May, Lisa A. Baer, Adam C. Lehnig,...

January 23, 2017

High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources.

Journal of Extracellular Vesicles, 2016, Haraszti et al – BERG collaborates with UMASS School of Medical to characterize the lipidome of exosomes and microvesicles Authors: Reka A. Haraszti, Marie-Cecile Didiot, Ellen Sapp, John Leszyk, Scott A....

January 23, 2017

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data

Non-obvious correlations to disease management unraveled by Bayesian artificial intelligence analyses of CMS data Authors: Vijetha Vemulapalli, Jiaqi Qu, Jeonifer M. Garren, Leonardo O. Rodrigues, Michael A. Kiebish, Rangaprasad Sarangarajan, Niven R. Narain, Viatcheslav R. Akmaev...